上海濯一科技 - 临床前小动物聚焦超声系统供应商

In 2026 5, Prof. Zhang Jing of Zhejiang University and Prof. Cheng Bingbing of ShanghaiTech achieved a major breakthrough through collaborative research, completing key experiments using our RK50 benchtop small-animal focused ultrasound system. The findings were published in a top-tier journal in neuroscience.Brain。

Research Background

Abnormal aggregation of α-synuclein is a key pathological feature of neurodegenerative diseases such as Parkinson's disease. Understanding how α-synuclein crosses the blood-brain barrier is critical for developing early diagnostic and therapeutic approaches.

Research Methods

The research team used the RK50 desktop small-animal focused ultrasound system with nanobubble contrast agents to achieve reversible opening of the blood-brain barrier. The RK50 system's precise focusing capability and acoustic feedback ensured experimental safety and reproducibility.

• Achieve precise blood-brain barrier opening with the RK50 system
• Monitor cavitation signals via acoustic feedback to ensure experimental safety
• Tracking red blood cell-derived α-synuclein using fluorescence labeling
• Validate blood-brain barrier opening using multimodal imaging

Key Findings

Research has found that red blood cells can serve as carriers for α-synuclein, enabling its transport across the blood-brain barrier into brain tissue. This discovery offers a new perspective on understanding the pathogenesis of neurodegenerative diseases and lays the foundation for developing early diagnostic biomarkers.

Contribution to the RK50 system

The RK50 desktop small animal focused ultrasound system played a pivotal role in this study:

• Precise Location:The 3D stereotactic brain frame achieves sub-millimeter precision, ensuring accurate delivery of ultrasound energy to the target brain region.
• Security Monitoring:The passive cavitation detection system monitors microbubble activity in real time and automatically assesses the degree of blood-brain barrier opening.
• Repeatability:Integrated design ensures consistent experimental conditions and enhances data reliability.
• Easy to use:Standardized workflows significantly reduce setup time and boost experiment efficiency.

Research Significance

This study not only reveals a new mechanism for the trans-blood-brain barrier transport of α-synuclein but also provides methodological reference for research on the delivery of other macromolecules. The RK50 system, as a key experimental tool, demonstrates its significant value in neuroscience research.